This README.txt file was generated on 2023-04-06 by Naiara Korta Martiartu 

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GENERAL INFORMATION
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Contributor information: 
Principal Investigators: Michael Jaeger, Institute of Applied Physics (IAP), University of Bern (michael.jaeger@unibe.ch)
			 Annalisa Berzigotti, Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
Data Collectors: Chiara Becchetti, Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
		 Patrick Stähli, Institute of Applied Physics (IAP), University of Bern
Data Curator: Naiara Korta Martiartu, Institute of Applied Physics (IAP), University of Bern (naiara.korta@unibe.ch)
Sponsor: Martin Frenz, Institute of Applied Physics (IAP), University of Bern
      
Date of data collection: August - November 2021

Location of data collection: Department for Visceral Surgery and Medicine at the University Hospital of Bern (Inselspital Bern, Switzerland) 

Keywords: ultrasound, speed of sound, hepatic steatosis, liver, controlled attenuation parameter, Diagnosis, Computed Ultrasound Tomography in Echo mode (CUTE)

Funding sources: Swiss National Science Foundation, Grant number: 05320_179038

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SHARING/ACCESS INFORMATION
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Related publication:  Patrick Stähli, Chiara Becchetti, Naiara Korta Martiartu et al. First-in-human diagnostic study of hepatic steatosis with computed ultrasound tomography in echo mode (CUTE), 06 September 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1920871/v1]

Please cite the accepted version of this publication in case you use the data.

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DATA & FILE OVERVIEW
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File List: 

Filename: Anonymized_CAP_and_SoS_data.csv
Short description: The data includes characteristics of study participants (i.e., sex, age, height, weight, cause of steatosis), the median and interquartile range of CAP measurements per participant, and the mean and the standard deviation of liver CUTE-SoS estimates per participant.
Abbreviations:  CAP = Controlled Attenuation Parameter (units dB/m) 
		SoS = Speed of sound in the liver estimated using Computed Ultrasound Tomography in Echo mode (CUTE)
		std = standard deviation
Date of creation: 2023-04-06

Filename: Statistical_Analysis.ipynb
File type: Jupyter notebook
Short description: A python-based jupyter-notebook that reproduces the statistical analysis of the publication [Patrick Stähli, Chiara Becchetti, Naiara Korta Martiartu et al. First-in-human diagnostic study of hepatic steatosis with computed ultrasound tomography in echo mode (CUTE), 06 September 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1920871/v1]].
This jupyter-notebook takes as input the previous file 'Anonymized_CAP_and_SoS_data.csv'.
Date of creation: 2023-04-06

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METHODOLOGICAL INFORMATION
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For details about the technical aspects and implementation of Computed Ultrasound Tomography in Echo mode (CUTE) for liver speed of sound estimations, please check:

M. Jaeger, P. Staehli, N. Korta Martiartu, P. Salemi Yolgunlu, T. Frappart, C. Fraschini, and 
M. Frenz, “Pulse-echo speed-of-sound imaging using convex probes,” Physics in Medicine & Biology,
vol. 67, no. 21, p. 215016, 2022